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Thats one reason why transdermal estrogenas opposed to oral estrogenis associated with a lower risk of blood clots

9 The emerging role of millifluidic platforms in translational applications While OoC platforms excel at replicating microscale tissue architectures and physiological shear stresses, their characteristic small volumes (nanoliters to microliters) can pose significant challenges for translational research

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doi: 10.1007/s40262-018-0728-4 35 KorsatkoSJensenLBrunnerMSach-FriedlSTarpMDHolstAGet al