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Representative images showing tubulin immunofluorescence in rat DRG neurons cultured with vehicle (A, control), with Oxm (B), exendin-4 (C), or GLP-1 (D)

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5.1 GIP and GLP-1 effects on pancreas 5.1.1 Effects on pancreatic -cell insulin secretion and survival Activation of either GIPR or GLP-1R on pancreatic -cells initiates distinct yet overlapping downstream signaling cascades that ultimately amplify glucose-stimulated insulin secretion