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Cortical arousal also takes advantage of dopaminergic neurons of the substantia nigra (SN), ventral tegmenti area (VTA) and the periaqueductal grey area (PAG)

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In 2014, the FDA granted AOD 9604 Human GRAS (Generally Recognized As Safe) status, indicating a favorable safety profile when used as directed

Causes of zinc deficiency: Chronic liver disease (up to 85% in cirrhosis)