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Thus, considering the increased potency combined with the greater availability of pro-IGF-I 39 , there is potential for optimizing therapies through the delivery or expression of the pro-IGF-I form

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This dual approach could theoretically offer a more complete strategy for improving metabolic health, especially for individuals facing significant challenges with obesity, insulin resistance, or age-related metabolic decline

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This randomised, double-blind, placebo-controlled trial enrolled 706 adults with overweight or obesity (BMI 27 or above) across multiple dose groups, running over 26 weeks