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Doing so can cause serious side effects, such as a fast or irregular heartbeat or increased blood pressure

In turn, the abnormal aggregation of -synuclein has been shown previously to increase brain excitotoxicity by affecting the transport efficiency of glutamate transporters and increasing the phosphorylation of NMDARs 12 , thus generating a vicious cycle involving excessive brain glutamate, excitotoxicity, and aberrant -synuclein aggregation

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Medical evaluation is essential

doi:10.1093/sleepadvances/zpaa002

In the SCALE Obesity and Prediabetes trial (Pi-Sunyer et al., NEJM 2015), participants receiving Saxenda alongside lifestyle modification achieved mean weight loss of approximately 8% of initial body weight, compared with 2.6% in the placebo group