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Unlike other VE compounds, T3-13'COOH, a natural metabolite of VE, has been shown to specifically activate (pregnane X receptor) PXR without being influenced by the pharmacological inhibition of PPAR activity [126]

However, the absence of endorsement from regulatory bodies raises significant concerns regarding the safety and efficacy of this practice

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GLP-1 receptor agonists are widely expressed in the brain, playing a role in reward and addiction pathways