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PMID: 18326937 Ji Y-L, Wang Z, Wang H, Zhang C, Zhang Y, Zhao M, Chen Y-H, Meng X-H, Xu D-X
Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species
In preclinical models, BPC157 has been shown to modulate expression of key inflammatory mediators by downregulating proinflammatory transcription factors such as NFB and AP1 while upregulating antiinflammatory genes linked to IL10 signaling, thereby shifting the balance toward resolution of inflammation in chronically injured tissues (24,25)
Am J Sports Med 35(3):427436 Peers KH, Lysens RJ (2005) Patellar tendinopathy in athletes: current diagnostic and therapeutic recommendations
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