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153 As a compensatory mechanism, IAPP may activate HIF-1/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) to protect against oligomer toxicity, thus delaying the loss of cells but at the cost of impairing cell function

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Epub 2017 Apr 13

Greater intrafollicular IGF-2 levels can explain why a 1.6-fold elevation in intrafollicular IGF-1 lacks any impact on follicular maturation in primates [13]