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In vitro research found that metformin activated a novel galectin-directed ubiquitin signal transduction system in response to lysosomal membrane damage, induces autophagy, and facilitates the elimination of M.tb from macrophages [117]

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Disease-associated p97 mutants lack this rotamer switch 29 , display a dynamic NTD 30 and no long-lived ADPP i state 11

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