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November 2023 : Eli Lilly received US FDA approval for ZEPBOUND, an obesity treatment that activates GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors

In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]

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This rapid weight loss from GLP-1 drugs like semaglutide (Ozempic) and tirzepatide (Mounjaro) decreases the amount of subcutaneous fat faster than skin can adjust

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Not a default dose