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The use of the Ca 2+ -sensitive receptor (CaSR) inhibitor NPS-2143 can block the carnitine-induced increase in the cytoplasmic Ca 2+ concentration, indicating that carnitine-induced Ca 2+ mobilization is mediated by the activation of CaSR [119]
doi: 10.1016/j.metabol.2017.08.014
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Gracias a su mecanismo de doble accin, esta nueva generacin de terapias ofrece el potencial de proporcionar beneficios ms amplios en el control glucmico, la reduccin del peso corporal y la mejora de mltiples alteraciones metablicas, en comparacin con los agonistas convencionales del receptor GLP-1
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