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Four (4) events of hypoglycemia defined as a plasma glucose less than 54 mg/dL occurred in 2 (1.6%) of 125 SAXENDA-treated patients and 1 event occurred in 1 (0.8%) of 126 placebo-treated patients

Directly, the copper coordination prevents free copper-catalyzed Fenton reactions that generate hydroxyl radicals, while the peptide sequence itself can scavenge existing reactive oxygen species

Reactions were stopped 16 hours later by addition of formic acid to a final concentration of 0.1%

[DOI] [PubMed] [Google Scholar] Perluigi M, Joshi G, Sultana R, Calabrese V, De Marco C, Coccia R, Cini C, Butterfield DA

doi: 10.21037/atm-21-1614 48 ShiQLiu R and ChenL

Stanford suspects it may be tied to a shift in sensory focus as GLP-1 users experience reduced food reward