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HR at 24 wk

Because retatrutide has shown more potent effects (and potentially more side-effects) youll want to proceed slowly under supervision

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15 As such, GIP, secreted by enteroendocrine K-cells, and GLP-1, released from corresponding intestinal L-cells, collectively referred to as the incretin hormones, are well-studied for their roles in glucose homeostasis and energy balance

They stimulate insulin secretion, inhibit glucagon release, and slow gastric emptying, potentially exerting protective effects on renal function 13

Appetite suppression is often strongest in the first part of the day, and many patients tell me they're simply not hungry which creates a real risk of under-eating protein and starting the day in a deficit they don't recover from by dinner