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One patient in the semaglutide group discontinued treatment due to severe nausea and vomiting, while the other patient in the metformin group discontinued treatment due to nausea and dyspepsia

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Cardiovascular and Metabolic Safety Because PT-141 may cause transient elevations in blood pressure, it is contraindicated in patients with uncontrolled hypertension or significant cardiovascular disease

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Gastric Emptying Effects : All forms of semaglutide significantly slow gastric emptying