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A large-scale, placebo-controlled clinical study shows a remarkable benefit from adding exenatide, a short-acting GLP-1 receptor agonist, to insulin glargine, on a background of metformin and/or pioglitazone, in patients with type 2 diabetes mellitus

Mechanistically, SM significantly enhanced -endorphin expression in the spinal dorsal horn and primary microglia [72]

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Similarly, no increased signal of arrhythmia, heart failure, or major cardiovascular events has emerged in the data published to date

The JMP Pro 17 software was utilized to conduct all analyses