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Accumulation of oxidized biomolecules associated with degeneration of DA neurons indicates the involvement of oxidative stress mechanisms [1], and the highly oxidizable aromatic structure of DA and its metabolites are thought to contribute to these processes [2]

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This combination acts as a signaling molecule, instructing cells to repair and regenerate

ZakkarMVan der HeidenKLuongLAChaudhuryHCuhlmannSHamdulaySSet alActivation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state

doi:10.1186/gm367