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The peptide is small enough (three amino acids plus a copper ion) to penetrate the stratum corneum, particularly when formulated with phospholipid-based delivery systems that enhance dermal absorption

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The substance is broadly safe in topical use at typical formulation concentrations of 0.05 to 0.2 percent

APAP adducts on mitochondrial proteins such as glycine amidinotransferase, Parkinson disease protein 7 (PARK7), peroxiredoxin 6 and voltage-dependent anion-selective channel protein 2 (VDAC2) have also been detected in cultures of human hepatocytes [34], indicating that adduct formation is not a global phenomenon affecting all mitochondrial proteins, but rather selective with specific targets

Loprinzi CL, Hershman DL, Staff N