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The stimulant-adjacent effect can cause mild anxiety or insomnia if taken late in the day

The vehicle (carrier) matters as much as the concentration for skin penetration

Although no confirmed genotoxic events in humans have been reported from the use of rAAV vectors to-date, given the above evidence, it will be imperative to perform further studies in larger model organisms (such as NHPs) with longer time points

GI events (nausea, vomiting, diarrhea) were the dominant safety signal and occurred at rates higher than reported for Phase 2 retatrutide and higher than for comparable dual or mono-agonist trials

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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11