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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes
10.1016/j.bioorg.2019.103333 86 VaishaliA.Hardeep SinghT.MousumiT.SaumyaS.ErinE
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What is cagrilintide and how does it work Cagrilintide is a long-acting amylin analogue developed by Novo Nordisk