Most studies evaluated oral supplements, not patches, and even the oral supplements showed questionable results, making it extremely unlikely that patches would have any meaningful effects on weight loss in humans
This creates a tent of tissue that ensures the needle enters the subcutaneous layer rather than going too deep
You should contact your GP if natural approaches to improving metabolic health have not yielded results after 3-6 months, if you have been diagnosed with type 2 diabetes or non-diabetic hyperglycaemia (pre-diabetes, HbA1c 42-47 mmol/mol), if you are struggling with obesity-related health complications, or if you experience unexplained weight changes, persistent fatigue, or excessive thirst and urination
Once applied, the patch uses a combination of permeation enhancers and micro-needles (depending on the technology) to deliver the medication through the outer layers of skin
On December 19, 2025, Eli Lilly announced that retatrutide produced 28.7% body weight loss in the Phase 3 TRIUMPH-4 trial
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