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Another essential component concerns pharmacokinetics (PK) and pharmacodynamics (PD)

Even with four-times-daily dosing ( = 6 h), R 1.12

During hypoglycaemia, insulin secretion is reduced and glucagon secretion is not inhibited

Mutated or dysfunctional ABCG2 may lead to significantly reduced excretion, moderate hyperuricemia and metabolic syndrome

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