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Inactivated PTEN has been found in various human cancers such as prostate cancer, breast cancer, and brain cancer (glioblastoma) (Roa et al

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In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]