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The reported outcome of this campaign was a candidate that retained agonist activity at amylin/calcitonin-family receptors while displaying a markedly extended pharmacokinetic profile in the authors' preclinical models, and reduced food intake in rodent models following administration

The migration of activated T lymphocytes, where they cause disease, has been shown for food allergen-specific and skin-homing T lymphocytes that are primed in the inflamed gut and migrate to the skin to cause atopic dermatitis

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