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Consistent with this, Insl5 increases food intake in a dose-dependent manner in nonfasted control mice, but these effects are not preserved in relaxin/insulin-like family peptide receptor 4 knockout mice, receptors expressed on enteric and vagal afferent neurons but not in the hypothalamus 235

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Transportation errors also account for a number of avoidable issues

After its synthesis, proinsulin finds a home in cytoplasmic secretory granules located close to the cell membrane