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High-dose biotin, also known as vitamin B7, can affect assays that use a biotin and streptavidin binding step, and the direction of the error depends on the assay format, with competitive designs prone to falsely high results and sandwich designs to falsely low ones

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In summary, here we will provide detailed descriptions of optimized assays to determine

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Within 12 months, the average dosage increased to 80 mcg/kg SC twice daily (range = 60 mcg/kg to 120 mcg/kg SC twice daily)