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Despite this conceptual shift, peptide mediators of bonemusclefat crosstalk remain among the most underexplored endocrine systems, in part because their biology challenges traditional organ-based models of metabolism

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Additionally, the GLP-1 signaling scores were closely related to immune-activating genes, MHC genes, chemokines and chemokine receptors in most types of cancer (Supplementary Figure S3), which indicated that the GLP-1 signaling is involved in immune response to tumor cells