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In some embodiments, the otic formulation or composition comprises about 0.6% by weight of the silicon dioxide

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Similar results were found in naturally aged mice 35

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It can be used as one of the markers for very long-chain (in ratio to tetradecanoylcarnitine) VLCADD or medium-chain (in ratio to octanoyl-L-carnitine) MCADD with acyl-CoA dehydrogenase deficiency