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[41] Arenas J, Huertas R, Campos Y, Daz AE, Villaln JM, Vilas E.FEBS Lett

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Downregulation of apoptosis-associated tyrosine kinase promotes iron accumulation via enhanced endosome recycling, sensitizing EGFR-TKI-resistant cells to ferroptosis inducers such as RSL3 (128)

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Our current understanding is that emodin can exert therapeutic effects through multiple pathways, including antioxidant, anti-inflammatory, and inhibition of CYP450