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Fletcher L, Kohli S, Sprague SM, Scranton RA, Lipton SA, Parra A, Jimenez DF, Digicaylioglu M: Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke

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One directly affects the somatotropic cells of the anterior pituitary, itself inhibiting further release of GH, whilst the other affects GH releasing hormone and somatostatin release from the hypothalamus to reduce the secretion of GH

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By day 21, the disease group continued to demonstrate significantly impaired performance, highlighting persistent motor dysfunction