Disruptions in iron metabolism leads to the accumulation of intracellular free iron, which catalyzes the generation of reactive oxygen species (ROS) through the Fenton reaction
In particular, by regulating the growth and proliferation of tumour cells, ferroptosis plays an unneglectable role in the occurrence and progression of various tumourous diseases
Necroptosis, pyroptosis, ferroptosis in sepsis and treatment
High specificity, little immune response, and prolonged tumor retention were evidenced
This may have happened with the EGF in the analyzed preparation
Moreover, it is now recognized that any cause of mucosal cell apoptosis can lead to this pigmentation, such as NSAIDs and IBD, which can also induce epithelial cell apoptosis.25 Some researchers have found that anthraquinone laxatives are decomposed by bacteria that consequently produce a type of rhubarb derivative in the caecum.26 The rhubarb derivative damages the intestinal epithelial cells and then promotes the effects of the laxative but then can lead to death of these cells, which are immediately engulfed by nearby macrophages
