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Mechanisms deciphered in these studies indicate that the interaction between serotonin and GLP-1 in the hindbrain increases proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neuron activity, leading to induction of satiety signals and suppression of neuropeptide Y/agouti-related peptide (NPY/AgRP) neuron activity, which in turn suppresses hunger

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Rotate injection sites, plan titration with Taper Coach, and learn your side-effect patterns

Some people barely notice anything at the starting dose, then get hit with significant sulfur burps when they move to the next dose level

PlexusDx providers can customize your titration schedule and starting dose based on your health history, significantly reducing headache risk during the adjustment phase

8 The time-response data and dose-response data are presented as the number of flinches in each phase