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For the semaglutide 1-mg-containing groups, semaglutide was initiated at 0.25 mg once weekly for the first 4 weeks, increased to 0.5 mg from weeks 5 to 8 and increased to 1.0 mg from weeks 9 to 71

Physiological Adaptation Some individuals may experience a natural plateau in weight loss over time

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If IGF-1 drops 1520% from peak despite protocol adherence, receptor downregulation is likely this signals the need to restructure the stack or implement a washout period

These medications affect hormone regulation, metabolism, and appetite control, which are key physiological aspects of weight management

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