This creates docking sites for IRS-1 (insulin receptor substrate 1), which then recruits PI3K through its p85 regulatory subunit
Carbone JW, Pasiakos SM
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Overall, when administering GLP-1RA plus SGLT2i combination therapy, it is important to adopt an individualized approach to therapy taking into account individual preferences, costs and coverage, AE profile, consideration of kidney function and glucose-lowering efficacy, desire for weight loss, and comorbidities such as frailty [6, 22, 24]
