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VD exerts antiepileptic effects by modulating the gut microbiota Emerging evidence suggests that VD suppresses the NF-kB p65-mediated MLCK-P-MLC signaling pathway via direct VDR-transforming growth factor--activated kinase 1 (TAK1) interactions, thereby ameliorating the altered localization of TJ proteins and preserving tight junction continuity in colonic organoids [107]

10.1016/j.ijbiomac.2025.145306 60 ZimmermannM.Zimmermann-KogadeevaM.WegmannR.GoodmanA

These gastrointestinal symptoms can lead to reduced oral intake and electrolyte imbalances, which pose greater risks in older individuals

The GLP-1 era: protein and fiber formulation innovation. Nutrition Insight (William Reed)

But your skin is used to having more volume underneath it

This dual mechanism appears to produce even greater effects on blood sugar and body weight than GLP-1-only medications