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However, early research found that GLP-1 had a short half-life in the body, limiting its therapeutic potentialthe problem: it needed to last longer to reach the pancreas

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It's important to note that when used as monotherapy, GLP-1 receptor agonists like semaglutide have a low risk of causing hypoglycemia

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The amplitude of low-frequency fluctuation (ALFF) is a measure of low-frequency signals in the brain, which correlates with the strength of local neural activity [45]