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Tang et al., Chemodynamic therapy: tumour microenvironment-mediated fenton and fenton-like reactions

Zoloft (sertraline) is a commonly prescribed selective serotonin reuptake inhibitor (SSRI) for mental health conditions, including obsessive-compulsive disorder (OCD)

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Oral doses of 0.55mg are most common in published research, but 4060% first-pass metabolism means actual CNS exposure is significantly lower than nominal dose

Accordingly, both APR and GCL in the primary metabolic pathway are activated upon oxidation whereas the activity of enzymes that are part of the secondary pathway, APK and SAL1, is attenuated