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Using a proper technique and the correct needle gauge can minimize discomfort, but it is generally considered a more invasive method.

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Although we did not directly assess chemical interactions (i.e., synergistic, additive, antagonistic), the reduced growth observed with ibuprofen and microplastics combined may suggest that in addition to an impaired digestive system, oxidative stress from ibuprofen likely contributed to the effects of microplastics alone (Srain et al., 2021

The Faseb Journal , 33 (4), 54685481

Late-stage diversification of peptides by metal-free CH arylation

doi: 10.1016/j.lfs.2004.04.019