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Macrophages are central to this process, orchestrating immune responses via cytokine secretion, phagocytosis of pathogens, apoptotic cells, and ECM debris, and facilitating tissue remodeling by releasing proteolytic enzymes and their inhibitors (135)

[PubMed] [Google Scholar] (439).Rawat SS

It also counteracts corresponding behavioral disturbances i.e

This often causes chronic inflammation, which can manifest as either chronic constipation or frequent diarrhea

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For gut-wall local effects (ulcer healing, intestinal permeability), the peptide does not need to cross the gut epithelium into systemic circulation