This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging ( The interplay between mitochondrial function and GSH is especially critical in PD
Overexpression of FSP1 or treatment with Fer-1, a ferroptosis inhibitor, significantly reversed the apoptosis, ferroptosis, and lipid peroxidation induced by the activation of the MPO/HOCl signaling pathway, exerting neuroprotective effects
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18 , who also reported behavioral disorders accompanying brain atrophy
113 MainaF.CasagrandaF.AuderoE.SimeoneA.ComoglioP
Petersburg Institute of Bioregulation and Gerontology, this synthetic tripeptide has emerged as a sophisticated molecular tool capable of modulating gene expression, enhancing cellular protection, and supporting fundamental biological processes including circadian rhythm regulation, neurological function, and metabolic homeostasis
