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Potential explanations for these discrepancies are off-target effects of the compounds as well as the use physiological GSH concentrations (1 mM) but non-physiological CDNB concentrations (1 mM) in the corresponding enzyme assays

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Antar A.A.R., Cox A.L

Additionally, curcumin exerts dual modulation of hepatocellular death pathways by promoting autophagy while inhibiting pyroptosis, thereby breaking the cycle of hepatocyte injury and cytokine-driven inflammation

2023 Jun;15(6):e40797

Together, these results indicated that the administration of peroxynitrite caused a reduced expression of GPX1 in cochlear SGNs, thus suggesting that GPX1 might play a role in peroxynitrite-induced SGN damage