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A surgery is generally considered minor if it doesnt require general anesthesia, the use of powerful drugs that send us to sleep so we dont move or feel pain during the procedure

Ruptures typically result from an acute mechanical overload to the extensor mechanism, such as with forced quadriceps contraction and knee flexion

152,153 It is worth mentioning that a major activator of TSC1/2 signalling is BDNF, a secreted protein that binds to the receptor tyrosine factor TrKB and is thereby involved in the PI3K/mTOR pathway

Both routes share systemic adverse event profiles that are compound-specific rather than route-specific