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Concerns about pancreatitis in incretin-based therapy have been raised due to mild elevations in amylase and/or lipase levels (75)

Seek care when you cannot keep liquids down, cannot urinate normally, feel faint or confused, have rapid weight loss, severe pain, fever, bleeding, leaking fluid, high blood pressure symptoms, chest pain, breathing difficulty, or reduced fetal movement

Regular communication with your healthcare provider, along with the use of reliable contraception, can help minimize these risks and provide clarity when needed

There are still situations where people shouldnt take certain weight-management medications

OSI-906 (linsitinib), a RTKI targeting both IGF-1R and IR, was investigated as a treatment for hormone sensitive breast cancer in combination with endocrine therapy and erlonitib in a phase II clinical trial (NCT01205685)

GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) are subcutaneous injections for type 2 diabetes and weight management