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Contrarily, Nrf2 related genes were reported to be upregulated and overexpressed in different cancers where they promote carcinogenesis and chemo resistance (46, 50, 51)

Further integration of proteome and metabolome profiling revealed an upregulation in production of antioxidants 66

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The CT60 polymorphism in the CTLA-4 gene has been identified as a significant factor influencing thyroid autoantibody production in patients with HT and PPT

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