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On average, tirzepatide has been shown in research to lead to a greater amount of weight loss : People with obesity in clinical trials for tirzepatide lost, on average, 20% of their body weight at week 72 (and about 7 inches off their waistlines), compared with about 14% of their body weight (and about 5 inches off their waistlines) with semaglutide

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Additionally, exogenous treatment with IGF-1 reduced TLR4 expression and reduced NF-B activation in lipopolysaccharide-induced inflammatory response of astrocytes [144]