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Nitric oxide is an unstable molecule that degrades quickly in the bloodstream, so it must be constantly replenished (16)

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The study protocol adhered to the Declaration of Helsinki and was approved by the review board of Renmin Hospital of Wuhan University (WDRY2021-KS047)

This means that even if you take 1000 mg or more, your body may only be absorbing a tiny fraction of that amount