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Mol Nutr Food Res 2015;59:1364-1372
Inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular disease and age-related neurodegenerative disease (e.g., Alzheimers disease)
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High-dose supplementation, particularly hydroxocobalamin injections, has been associated with acne-like eruptions and rosacea flare-ups in susceptible individuals
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This direct approach ensures that the vitamin is absorbed efficiently, especially in individuals who may have difficulty absorbing B12 through the digestive tract due to certain health conditions
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