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Molecular structure of DPP-4 Initially described by Hopsu-Havu & Glenner in 1966 [25], DPP-4 is a dimeric 240-kDa glycoprotein composed of two 120-kDa subunits and encoded by a gene located in chromosome 2q24 [25]

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GLP-1, the second incretin, was discovered in 1987.GLP-1 stimulates insulin secretion in a glucose concentration-dependent manner at glucose level above 4.3 mmol/l

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doi: 10.1016/j.heliyon.2023.e19763 202 RodriguezJBystrynJC