However, limitations include in vivo instability, reliance on biocompatible and robust carriers and restricted application procedures (local and direct)
That is one reason FDA staff and several committee members resisted treating patient demand or clinician experience as a substitute for controlled evidence
Serum levels of total vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and total homocysteine (tHcy) were measured on days 0, 7, 14, 30, 60, and 90
Formula fed infants will never develop this specific gut microbiome
The safety profile appears favorable for extended use based on available data, though long-term studies specifically on oral formulations do not exist
Why the off phase matters: the 2 month break preserves pituitary responsiveness across multiple cycles