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If you follow a plant-based diet, it is generally recommended to consult your healthcare provider, who can perform a blood test to confirm whether you have low blood levels of vitamin B12 and if supplementation or intramuscular B12 injections are necessary

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The titration protocol exists for safety reasons that are independent of any co-administered compound

Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

Toxins 12 (7), 451