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Patients are advised to have their last meal at least three hours before going to sleep

Abudawood M, Tabassum H, Alanazi AH, et al

doi: 10.3109/14767058.2011.573827 12 ReiterRJTanDXManchesterLCParedesSDMayoJCSainzRM

Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug [see OVERDOSAGE ]for toxicity information

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GLP-1 Action: Similar to semaglutide, tirzepatide activates GLP-1 receptors, contributing to delayed gastric emptying, appetite suppression, and improved blood sugar regulation